Relation between leptin and the regulation of glucose metabolism

The identification of the ob gene through positional cloning and the discovery that its encoded protein, leptin, is essential for body weight homeostasis have permanently altered the field of metabolic physiology.

Over a 5-year period a substantial and rapidly changing body of knowledge has been created.

CITA DEL ARTÍCULO  Diabetologia. 2000 Jan;43(1):3-12