Cytogenetic marker del(12p) in a case of acute myeloid leukemia M4 with eosinophilia and inv(16)

A 35-year-old Spanish female having acute myelomonocytic leukaemia with marrow eosinophilia is reported. The karyotype revealed the specific chromosomal abnormality associated with this disorder, inv(16), and a less-specific myelodysplastic cytogenetic marker, del(12p).

We have reviewed the published cases in order to elucidate the possible significance of presenting a 12p deletion (nonrandomly associated with chronic myelomonocytic leukaemia) together with other chromosomal rearrangements.

CITA DEL ARTÍCULO  Sangre (Barc). 1992 Apr;37(2):125-7