Articular cartilage degeneration after frozen meniscus and Achilles tendon allograft transplantation: experimental study in sheep
Mora G., Álvarez E., Ripalda P., Forriol F.
Laboratory for Experimental Orthopaedics, School of Medicine, University of Navarra, Pamplona, Spain
Fecha: 01/10/2003Cirugía Ortopédica y Traumatología
The purpose of this study was to analyze cartilage degeneration in knees after total medial meniscectomy, transplantation of fresh-frozen meniscus allograft, and Achilles tendon allograft.
TYPE OF STUDY
We have studied the articular cartilage in the medial compartment of the left knees in 32 sheep aged 5 to 6 months, with 8 animals in each group. The study was performed after meniscectomy (group I), transplantation of fresh-frozen meniscus allograft (group II), use of fresh-frozen Achilles tendon allograft (group III), and in a control group (group IV).
For the histologic study, all samples were stained with Masson's trichrome and Safranine-O. Mankin's score was applied to grade the histologic damage to the articular cartilage.
The group with the greatest number of degenerative changes was group III, followed by groups I and II. The percentage of thickness of cartilage detected by Safranine-O stain was found to be significantly different in both tibia and femur between the control group and the other 3 groups, but not among groups I, II, and III.
The immunoreactivity of the articular surfaces in tibia and femur showed notable differences in all the groups. Collagen X was present in the degenerative hypertrophic chondrocytes in the damaged articular surfaces.
Meniscal replacement with meniscal and Achilles tendon allografts provides partial protection against articular damage after a meniscectomy.
CITA DEL ARTÍCULO Arthroscopy. 2003 Oct;19(8):833-41
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