Verapamil deleterious effects in chronic renal failure
C. Vázquez (a), A. Huelmos (b), E. Alegría (b), P. Errasti [SP] (a), A. Purroy (a)
Departments of (a) Nephrology and (b) Cardiology, Clínica Universitaria, Universidad de Navarra, Pamplona, Spain
Date: Oct 1, 1999Cardiology Nephrology [SP]
Three hypertensive patients with chronic renal failure treated with slow-release verapamil at the recommended doses for high blood pressure experienced acute deleterious effects shortly after treatment (6 h to 3 days). Patients developed slow cardiac rhythms (junctional bradycardia or atrial fibrillation), hypotension and hyperkalemia.
Consequently they also had oliguria and worsening of the renal function. Inotropic support, fluid therapy and potassium-lowering measures were able to restore the renal function and sinus rhythm after 10-12 h.
Only 7 similar cases have been described so far. It is suggested that slow-release formulations of verapamil must be used with caution in hypertensive patients with impaired renal function.
CITATION Nephron. 1996;72(3):461-4
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