Synthesis of S-[13N]nitrosoglutathione (13N-GSNO) as a new potential PET imaging agent
Llop J, Gómez-Vallejo V, Bosque M, Quincoces G [SP], Peñuelas I. [SP]
Institut Alta Tecnologia PRBB - Fundació Privada, Parc de Recerca Biomèdica de Barcelona, C. Dr. Aiguader, 88, 08003 Barcelona, Spain
Magazine: Applied Radiation and Isotopes
Date: Jan 1, 2009Nuclear Medicine [SP]
In the present paper, a fast and reproducible method for the synthesis of S-[(13)N]nitrosoglutathione is reported for the first time.
The labeling strategy is based on the production of [(13)N]NO(3)(-) via the (16)O(p,alpha)(13)N nuclear reaction in water, as opposed to the standardized production of [(13)N]NH(4)(+) in 2mM aqueous ethanol.
Following the reduction of [(13)N]NO(3)(-) to [(13)N]NO(2)(-), the reaction with glutathione in the presence of hydrochloric acid led to the desired radiotracer with a good radiochemical yield (24.2+/-2.0% end of synthesis, n=5) in a short production time (3min from the end of bombardment).
CITATION Appl Radiat Isot. 2009 Jan;67(1):95-9
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