Subsequent nonmelanoma skin cancer after liver transplantation
Herrero JI, España A, D'Avola D [SP], Pardo F, Iñarrairaegui M [SP], Rotellar F, Sangro B, Quiroga J. [SP]
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), and the Liver Unit, Clinica Universidad de Navarra, Pamplona, Spain
Magazine: Transplantion Proceedings
Date: Jul 1, 2012Dermatology General and Digestive Surgery Hepatology Liver and Pancreatic Tumours Area
Liver transplant recipients have a high risk of developing nonmelanoma skin cancer (NMSC). Some develop multiple NMSC.
Patients with a follow-up of >1 year have been prospectively followed to detect NMSC. We studied the risk of developing >1 NMSC.
After a follow-up of 2658 patient-years (mean, 8.5 years per patient), 59/312 (19%) patients were diagnosed with NMSC. Twenty-five had >1 NMSC. The 5-year risk of developing 1 NMSC, >1 NMSC, and a subsequent NMSC (a new NMSC after a first one) were 15%, 5.5%, and 46.5%, respectively. Age >60 years and transplantation for hepatocellular carcinoma were independently associated with a higher risk of developing >1 NMSC.
NMSC are frequent complications after liver transplantation and they may show a high rate of recurrence. Older age and hepatocellular carcinoma were related to the development of multiple NMSC.
CITATION Transplant Proc. 2012 Jul;44(6):1568-70
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