Scientific publications

Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson's disease

Alonso-Frech F, Zamarbide I, Alegre M [SP], Rodríguez-Oroz MC, Guridi J, Manrique M, Valencia M, Artieda J [SP], Obeso JA.
Department of Neurology and Neurosurgery, Neuroscience Area, Clinica Universitaria and Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra Pamplona, Spain.

Magazine: Brain

Date: Jul 1, 2006

Neurophysiology [SP] Neurology [SP]

The pathophysiology of levodopa-induced dyskinesias (LID) in Parkinson’s disease is not well understood.

We have recorded local field potentials (LFP) from macroelectrodes implanted in the subthalamic nucleus (STN) of 14 patients with Parkinson’s disease following surgical treatment with deep brain stimulation. Patients were studied in the ‘Off’ medication state and in the ‘On’ motor state after administration of levodopa–carbidopa (po) or apomorphine (sc) that elicited dyskinesias in 11 patients. The logarithm of the power spectrum of the LFP in selected frequency bands (4–10, 11–30 and 60–80 Hz) was compared between the ‘Off’ and ‘On’ medication states.

A peak in the 11–30 Hz band was recorded in the ‘Off’ medication state and reduced by 45.2% (P < 0.001) in the ‘On’ state. The ‘On’ was also associated with an increment of 77. 6% (P < 0.001) in the 4–10 Hz band in all patients who showed dyskinesias and of 17.8% (P < 0.001) in the 60–80 Hz band in the majority of patients. When dyskinesias were only present in one limb (n = 2), the 4–10 Hz peak was only recorded in the contralateralSTN.

These findings suggest that the 4–10 Hz oscillation is associated with the expression of LID in Parkinson’s disease.

CITATION  Brain. 2006 Jul;129(Pt 7):1748-57

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