Scientific publications

Risk factors for recurrence of hepatitis C after liver transplantation

Herrero JI, de la Peña A, Quiroga J [SP], Sangro B, García N [SP], Sola I, Cienfuegos JA, Civeira MP [SP], Prieto J.
Liver Unit, Clínica Universitaria de Navarra, Pamplona, Spain.

Magazine: Liver Transplantation and Surgery

Date: Jul 1, 1998

Pathological Anatomy [SP] Hepatology

Recurrent hepatitis C is a frequent complication after liver transplantation for hepatitis C virus-related cirrhosis, but risk factors related to its development remain ill defined.

Twenty-three patients receiving a primary liver graft for hepatitis C virus-related cirrhosis and with an assessable biopsy performed at least 6 months after liver transplantation were studied retrospectively. The end point of this study was to look for risk factors associated with the development of histologic hepatitis C in the graft. Thirty-six major variables were studied, and those reaching significance by univariate analysis were included in a multivariate analysis. Eighteen patients (78%) developed posttransplant hepatitis C. On univariate analysis, six variables showed significant predictive value: increased immunosuppression for treatment of acute rejection; pretransplant hepatocellular carcinoma; cumulative doses of prednisone at 3, 6, and 12 months after transplantation; and mean blood trough levels of cyclosporine in the first 6 months posttransplantation.

On multivariate analysis, two variables retained independent statistical significance as predictors of hepatitis C recurrence, namely receipt of antirejection therapy (P = .0087) and lower mean cyclosporine levels in the first 6 months after transplantation (P = .0134).

Therefore, recurrence of hepatitis C after liver transplantation seems to be at least partially related to posttransplantation immunosuppressive therapy.

CITATION  Liver Transpl Surg. 1998 Jul;4(4):265-70

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