Scientific publications

Prevalence of hypercoagulation conditions in patients with thrombosis in Northern Navarra

Benedicto Aguirre E, Yuste JR [SP], Páramo JA, Rocha E, Prieto J.
Departamento de Medicina Interna, Clínica Universitaria de Navarra, Pamplona

Magazine: Anales de Medicina Interna

Date: Sep 1, 1997

Haematology and Hameotherapy Internal Medicine [SP]

BACKGROUND
To determine the prevalence of hypercoagulability states in patients with thromboembolic disease in Septentrional Navarra.

PATIENTS AND METHODS
74 patients were studied (13 female, mean age [+/- SD] 43.5 +/- 13.9 years, range 22-81) with: deep venous thrombosis (DVT) with or without pulmonary embolism (PE) in 15 patients; ischemic stroke (IS) in 20 patients and; myocardial infarction (MI) in 39 patients. Antithrombin III, C protein (CP), plasminogen, plasminogen activator inhibitor (PAI), total S protein (TSP), free S protein (FSP), lupus anticoagulant (LA) and anticardiolipin antibodies (ACA) type IgG were determined in all patients.

RESULTS
The prevalence of hypercoagulability state was 27% in patients with thromboembolic disease; 26.6% in patients with PE (20% with ACA and 6.6% with CP deficiency); 30% in patients with IS (15% with ACA, CP deficiency in 5%, FSP deficiency in 5%, and PAI raising in 10%) and in the 25.6% of patients with MI (15.3% with ACA, 2.5% with CP deficiency, 2.5% with TSP and FSP deficiency and PAI raising in the 7.6%).

CONCLUSIONS
In Septentrional Navarra population with thromboembolic disease the presence of hypercoagulable states is high. In our study, the most common hypercoagulable state was the presence of ACA, followed by PAI raising and by the CP deficiency.

CITATION  An Med Interna. 1997 Sep;14(9):450-4

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