Perioperative high dose rate brachytherapy in previously irradiated head and neck cancer: Results of a phase I/II reirradiation study
Martínez-Fernández MI (1), Alcalde J [SP] (2), Cambeiro M [SP] (1), Peydró GV (1), Martínez-Monge R (3).
(1) Department of Oncology, Clínica Universidad de Navarra, Spain.
(2) Department of Otolaryngology, Clínica Universidad de Navarra, Spain.
(3) Department of Oncology, Clínica Universidad de Navarra, Spain.
Magazine: Radiotherapy and Oncology
Date: Oct 13, 2016Radiation Oncology Otorhinolaryngology
BACKGROUND AND PURPOSE:
This study was undertaken to determine the feasibility of salvage surgery and PHDRB in patients with previously irradiated, recurrent head and neck cancer or second primary tumors arising in a previously irradiated field.
METHODS AND MATERIALS:
Sixty-three patients were treated with surgical resection and PHDRB. The PHDRB dose was 4Gy b.i.d.×8 (32Gy) for R0 resections and 4Gy b.i.d.×10 (40Gy) for R1 resections, respectively. Further external beam radiotherapy or chemotherapy was not given.
Resections were categorized as R0 in 7 patients (11.1%) and R1 in 56 (88.9%). Thirty-four patients with R1 resections (54.0%) had microscopically positive margins, and 22 patients (34.9%) had close margins.
Thirty-two patients (50.8%) developed RTOG grade 3 or greater adverse events including 3 fatal events. After a median follow-up of 6.8years, the 5-year locoregional control rate and 5-year overall survival rates were 55.0% and 35.6%, respectively.
Surgical resection and PHDRB is a successful treatment strategy in selected patients with previously irradiated head and neck cancer. Long-term locoregional control can be achieved in a substantial number of cases despite a high rate of inadequate surgical resections although at the expense of substantial toxicity.
CITA DEL ARTÍCULO Radiother Oncol. 2016 Oct 13. pii: S0167-8140(16)34287-6. doi: 10.1016/j.radonc.2016.08.023
you maybe interested
The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.
The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.
Learn why we are different from other healthcare centers. Quality, speed, comfort and results.