Scientific publications

Front-line paclitaxel/cisplatin-based chemotherapy in brain metastases from non-small-cell lung cancer

Cortés J. (1), Rodríguez J. [SP] (1), Aramendía J.M. [SP] (1), Salgado E. (1), Gúrpide A. [SP] (1), García-Foncillas J. (1), Aristu J.J. [SP] (1), Claver A. (1), Bosch A. (1), López-Picazo J.M. [SP] (1), Martín-Algarra S. (1), Brugarolas A. (2), Calvo E.(2) 
(1) Departments of Oncology and Radiation Oncology, Clínica Universitaria de Navarra, Pamplona
(2) Department of Oncology, San Jaime Hospital, Partida de la Loma, Torrevieja, Spain

Magazine: Oncology

Date: Jan 1, 2003

Radiation Oncology Medical Oncology

Paclitaxel-cisplatin is considered to be a standard therapy for metastatic non-small-cell lung cancer (NSCLC). The aim of this study was to evaluate the activity and toxicity of this combination with vinorelbine or gemcitabine as front-line therapy in brain metastases from NSCLC.

Twenty-six chemotherapy-naive patients with an ECOG performance status of 0-2 were treated with paclitaxel (135 mg/m(2)) on day 1, cisplatin (120 mg/m(2)) on day 1, and either vinorelbine (30 mg/m(2)) on days 1 and 15 or gemcitabine (800 mg/m(2)) on days 1 and 8. Whole-brain irradiation was offered early in case of progression and later as consolidation treatment.

All patients were evaluated for toxicity and 25 for response. An intracranial response rate was observed in 38% of the patients (95% CI: 22-59%). WHO grade 3-4 neutropenia and thrombocytopenia occurred in 31 and 4% of the patients, respectively. There was one treatment-related death. Non-hematological toxicities were mild. After a median follow-up of 46 months, the median overall survival for all patients was 21.4 weeks and the median time to progression was 12.8 weeks.

Paclitaxel and cisplatin combined with vinorelbine or gemcitabine as front-line therapy in brain metastases seem to achieve responses similar to those for extracranial disease, suggesting a meaningful role in this setting.

CITATION  Rev Clin Esp. 1997 Jun;197(6):434-46



The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra


Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra