Scientific publications

Nuclear factor k B is activated in myelodysplastic bone marrow cells

Sanz C, Richard C, Prosper F, Fernandez-Luna JL.

Magazine: Haematologica

Date: Sep 1, 2002

Cell Therapy Area [SP]

We describe a significant increase in the DNA binding activity of nuclear factor-kappa B (NF kappa B) in bone marrow cells from patients with myelodysplastic syndrome (MDS) compared with normal donor cells.

Furthermore, MDS samples with increased NFkappaB activity consistently showed higher mRNA levels of NFkappaB-regulated cytokines.

CITATION  Haematologica. 2002 Sep;87(9):1005-6

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