Neoadjuvant intra-arterial chemotherapy in inflammatory carcinoma of the breast
Bilbao JI, Rebollo J, Longo JM, Mansilla F, Muñoz-Galindo L, Vieitez JM.
Department of Radiology, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain
Magazine: The British Journal of Radiology
Date: Mar 1, 1992Breast Cancer Area Radiology [SP]
From 1982 to 1989, 18 eligible patients (median age 50.5 years, range 30-72 years) with inflammatory breast carcinoma have been treated with neoadjuvant intra-arterial (IA) chemotherapy. The treatment regimen includes IA cisplatin, adriamycin, mytomycin C and thiotepa on Day 1 and intravenous 5-fluorouracil on Days 1 and 2. An objective clinical response rate of 100% (eight complete and 10 partial) has been observed.
The median disease-free and overall survivals are 27 months (range 5-85+ months) and 33 months (range 8-85+ months), respectively. With a median follow-up of 21.5 months, six (33.3%) patients remain alive and free of disease and 12 patients have died because of distant metastases. No local recurrences have been observed.
Intra-arterial chemotherapy is an attractive technique for the treatment of locally advanced breast carcinoma with mild toxicity and high local control rate.
CITATION Br J Radiol. 1992 Mar;65(771):248-51
you maybe interested
The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.
The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.
Learn why we are different from other healthcare centers. Quality, speed, comfort and results.