Modulation of beta 2-adrenoceptors in lymphocytes of allergic patients after in vitro antigenic stimulation
de la Cuesta CG, Sanz ML, Gamboa PM, Diéguez I, Oehling A.
Department of Allergology and Clinical Immunology, Faculty of Medicine, University of Navarra, Pamplona, Spain
Magazine: Journal of Investigational Allergology and Clinica Immunology
Date: May 1, 1993Allergology and Immunology Department
In this study, we assessed the effect of antigen-specific stimulation on beta-adrenoceptors of human lymphocytes in order to study the beta-receptor atopy theory of Szentivanyi. Determination of these receptors was basically carried out as described by Brodde et al., utilizing [125I]-cyanopindolol as ligand in control and allergic patients before and after stimulation with specific antigen.
We found that in vitro the specific antigen-antibody reaction induces a decrease in beta-adrenoceptors. This alteration takes place in patients with rhinitis and asthma with sensitization to Dermatophagoides and grass pollen, regardless of their baseline clinical status.
Therefore, in view of the results, we question the validity of Szentivanyi's atopy theory. We hypothesize that the modification in the beta-adrenoceptor system is a consequence rather than the cause of the activity of atopic diseases.
CITATION J Investig Allergol Clin Immunol. 1993 May-Jun;3(3):130-5
you maybe interested
The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.
The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.
Learn why we are different from other healthcare centers. Quality, speed, comfort and results.