Lysostaphin and clarithromycin: a promising combination for the eradication of Staphylococcus aureus biofilms.
Aguinaga A, Francés ML, Del Pozo JL [SP], Alonso M [SP], Serrera A, Lasa I, Leiva J [SP].
Department of Clinical Microbiology, Clínica Universidad de Navarra, Avda. de Pío XII 36, 31008 Pamplona, Navarra, Spain
Magazine: International Journal of Antimicrobial Agents
Date: Jun 1, 2011Infectious Diseases [SP] Clinical Microbiology [SP]
The difficulty of treating biofilm-associated infections has inspired the study of new treatment targets as well as combinations of new substances and antimicrobials with different mechanisms of action.
Lysostaphin is an endopeptidase extracted from Staphylococcus simulans biovar staphylolyticus that cleaves the pentaglycine cross-links in the cell walls of Staphylococcus spp., lysing bacteria.
CITATION Int J Antimicrob Agents. 2011 Jun;37(6):585-7
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