Scientific publications

Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism

Del Pozo JL [SP] (1), Fernández-Ros N (2), Sáez E (3), Herrero JI (4), Yuste JR [SP] (2), Banales JM (5).
(1) Infectious Diseases Division, Clinica Universidad de Navarra, Pamplona, Spain Department of Clinical Microbiology, Clinica Universidad de Navarra, Pamplona, Spain 
(2) Infectious Diseases Division, Clinica Universidad de Navarra, Pamplona, Spain Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain.
(3) Division of Gene Therapy and Hepatology, School of Medicine and CIMA of the University of Navarra, Pamplona, Spain Department of Liver and Gastrointestinal Diseases, National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, funded by the Spanish Carlos III Institute), Barcelona, Spain.
(4) Department of Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain.
(5) Division of Gene Therapy and Hepatology, School of Medicine and CIMA of the University of Navarra, Pamplona, Spain Department of Liver and Gastrointestinal Diseases, National Institute for the Study of Liver and Gastrointestinal Diseases (CIBERehd, funded by the Spanish Carlos III Institute), Barcelona, Spain Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of Basque Country (UPV), IKERBASQUE (Basque Foundation for Science), San Sebastián, Spain.

Magazine: Antimicrobial Agents and Chemotherapy

Date: May 5, 2014

Clinical Microbiology [SP] Internal Medicine [SP] Infectious Diseases [SP]

ABSTRACT

Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms.

Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.

CITATION  Antimicrob Agents Chemother. 2014 Jul;58(7):4227-9. doi: 10.1128/AAC.02856-14. Epub 2014 May 5.

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