Scientific publications

Leptin does not respond to 48 h fat deposition or mobilization in women

Murgatroyd PR, Frühbeck G [SP], Goldberg GR, Jebb SA, Leahy FE, Moore MS, Prentice AM.
MRC Dunn Clinical Nutrition Centre, Cambridge, UK

Magazine: International Journal of Obesity Related Metabolic Disorders

Date: Apr 1, 2003

Obesity Unit Endocrinology and Nutrition [SP]

Objective
To test the hypothesis that acute responses of plasma leptin concentration to energy balance manipulation are mediated by fat flux.

Design
Ten healthy women aged 31-63 y, mass 48-113.5 kg, fat mass 8.5-62.5 kg, were studied for 3 days in a whole-body calorimeter on two occasions. After a control day (D1) during which energy balance was maintained, diet was manipulated to induce fat deposition (FD) or mobilization (FM) of 50 g/day for 2 days (D2 & D3). A difference totalling of 194+/-18.6 g fat was achieved between manipulations without significant effects on carbohydrate or protein balance. Fasting plasma leptin was measured on D2 and D4.

Results
After the control day plasma leptin concentration averaged 19.01+/-9.8 ng/ml, and was found to be linearly related to body fat mass. After 2 days manipulation of fat balance, leptin concentrations were 21.4+/-10.3 ng/ml (FD) and 21.2+/-11.3 ng/ml (FM). There was no significant difference between treatments in either control day or postmanipulation leptin concentrations, nor did the treatments induce any differences in glucose or insulin concentration responses.

Conclusions
Although in states of energy balance leptin concentration is linearly related to fat mass, acute modulation of leptin concentration during energy imbalance is not mediated by fat flux.

CITATION  Int J Obes Relat Metab Disord. 2003 Apr;27(4):457-62

tal vezLE INTERESE

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra