Scientific publications

LC method for the therapeutic drug monitoring of lamotrigine: evaluation of the assay performance and validation of its application in the routine area

L. Zufía (a), A. Aldaz [SP] (a), N. Ibáñez (a), C. Viteri [SP] (b)
(a) Pharmacy Department, University Hospital of Navarra, c/Pío XII s/n, 31008 Pamplona, Spain
(b) Neurology Department, University Hospital of Navarra, c/Pío XII s/n, 31008 Pamplona, Spain

Magazine: Journal of Pharmaceutical and Biological Analysis

Date: Feb 20, 2009

Neurology [SP] Pharmacy [SP]

An accurate and precise high-performance liquid chromatographic method using diode array detection for the determination of lamotrigine in human plasma has been developed and validated for use in pharmacokinetic studies.

A validation strategy based on the accuracy profiles was used to select the most appropriate regression model and to determine the limits of quantitation as well as the concentration range.

On the other hand, the present paper also shows this validation approach as a suitable tool to guaranty the quality of the results obtained by the use of the analytical validated methodology for plasma lamotrigine determination in a routine setting and to ensure the risk of obtaining the future measurements outside the previously fixed acceptance limits.

CITATION J Pharm Biomed Anal. 2009 Feb 20;49(2):547-53

you maybe interested

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra