Intensive chemotherapy in the treatment of patients with metastatic breast cancer
Magazine: Revista de Medicina de la Universidad de Navarra
Date: Jul 1, 1997Radiation Oncology Breast Cancer Area Medical Oncology
Phase II study with intensive chemotherapy and autologous stem cells support in patients with metastatic breast cancer.
Forty-nine patients were treated with high-doses of two cytotoxic drugs and support with stem cells obtained from several leukapheresis without movilitation. The cells were reinfused forty-eight hours after finishing the administration of chemotherapy.
Twenty-one patients (47%, CI-95%: 32.4-63.3%) achieved a complete remission. The objective responses rate was 73% (CI-95%: 57.2-85%). Overall and progression-free survival up to 4 years were 31% and 20%, respectively. Ten patients remain progression-free among 17 and 46 months. The most frequent extramedullary toxicity was hepatic and renal. Three patients (6%) died during the procedure.
Intensive chemotherapy with hematopoietic support yields, with a moderate toxicity, a high objective response and complete remission rate. A small group of patients achieves a long progression-free survival.
CITATION Rev Med Univ Navarra. 1997 Jul-Sep;41(3):143-51
you maybe interested
The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.
The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.
Learn why we are different from other healthcare centers. Quality, speed, comfort and results.