Scientific publications

Intensive chemotherapy in the treatment of patients with metastatic breast cancer

Salgado J.E., Aramendía J.M. [SP], Fernández-Hidalgo O.A., Lozano E., Rebollo J., Martínez-Monge R., Subirá M.L., Brugarolas A.
Departamento de Oncología, Facultad de Medicina, Universidad de Navarra

Magazine: Revista de Medicina de la Universidad de Navarra

Date: Jul 1, 1997

Radiation Oncology Breast Cancer Area Medical Oncology

PURPOSE
Phase II study with intensive chemotherapy and autologous stem cells support in patients with metastatic breast cancer.

METHODS
Forty-nine patients were treated with high-doses of two cytotoxic drugs and support with stem cells obtained from several leukapheresis without movilitation. The cells were reinfused forty-eight hours after finishing the administration of chemotherapy.

RESULTS
Twenty-one patients (47%, CI-95%: 32.4-63.3%) achieved a complete remission. The objective responses rate was 73% (CI-95%: 57.2-85%). Overall and progression-free survival up to 4 years were 31% and 20%, respectively. Ten patients remain progression-free among 17 and 46 months. The most frequent extramedullary toxicity was hepatic and renal. Three patients (6%) died during the procedure.

CONCLUSIONS
Intensive chemotherapy with hematopoietic support yields, with a moderate toxicity, a high objective response and complete remission rate. A small group of patients achieves a long progression-free survival.

CITATION Rev Med Univ Navarra. 1997 Jul-Sep;41(3):143-51

you maybe interested

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra