Inhibition of acquired immunodeficiency syndrome virus by oligodeoxynucleoside methylphosphonates.
Sarin PS, Agrawal S, Civeira MP, Goodchild J, Ikeuchi T, Zamecnik PC.
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892
Magazine: Proceedings of the National Academy of Sciences of the United States of America
Date: Sep 30, 1988Internal Medicine [SP]
Antisense oligodeoxynucleotides containing internucleoside methylphosphonate linkages were examined for their ability to inhibit human immunodeficiency virus (HIV)-induced syncytium formation and virus expression.
HIV inhibitory activity was found to be dependent on both chain length and the number of phosphonate residues. Introduction of 18 phosphonate groups in an oligomer of chain length 20 significantly increased HIV inhibitory activity relative to the parent oligonucleotide, whereas 5 such groups showed little or no increase in the HIV inhibition capacity.
Methylphosphonate-linked oligomers are more stable to nuclease degradation and hence could be potentially useful in the treatment of acquired immunodeficiency syndrome.
CITATION Proc Natl Acad Sci U S A. 1988 Oct;85(20):7448-51
you maybe interested
The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.
The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.
Learn why we are different from other healthcare centers. Quality, speed, comfort and results.