Immunosuppression routed via the kynurenine pathway: a biochemical and pathophysiologic approach
Magazine: Advances in Clinical Chemistry
Date: Jun 1, 2008Immunology [SP] Biochemistry [SP]
In the past years, it has been shown that kynurenines pathway is a regulator of both the innate and the adaptive immune responses. Particularly, the initial enzyme of this pathway, indoleamine 2,3-dioxygenase (IDO), is implicated in maintaining tolerance during pregnancy, and also can be expressed in tumors to avoid the immune attack.
In this chapter, we will describe how the kynurenine pathway affects the immune system with important implications both in physiology and in pathology.
The incorrect activation or blockade suppressive properties of the kynurenine pathway are also implicated in a number of other diseases such as AIDS or autoimmune diseases.
CITATION Adv Clin Chem. 2008;45:155-97
you maybe interested
The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.
The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.
Learn why we are different from other healthcare centers. Quality, speed, comfort and results.