Scientific publications

Generation of iPSC from cardiac and tail-tip fibroblasts derived from a second heart field reporter mouse

Linares J (1), Arellano-Viera E (1), Iglesias-García O (1), Ferreira C (2), Iglesias E (1), Abizanda G (1), Prósper F (3), Carvajal-Vergara X (1).
(1) Cell Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
(2) Genetic Analysis Core Facility, University of Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
(3) Cell Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain; Cell Therapy Area, Clínica Universidad de Navarra, University of Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain. 

Magazine: Stem Cell Research

Date: May 1, 2016

Cell Therapy Area [SP]

ABSTRACT

Mef2c Anterior Heart Field (AHF) enhancer is activated during embryonic heart development and it is expressed in multipotent cardiovascular progenitors (CVP) giving rise to endothelial and myocardial components of the outflow tract, right ventricle and ventricular septum.

Here we have generated iPSC from transgenic Mef2c-AHF-Cre x Ai6(RCLZsGreen) mice. These iPSC will provide a novel tool to investigate the AHF-CVP and their cell progeny.

CITATION  Stem Cell Res. 2016 May;16(3):617-21. doi: 10.1016/j.scr.2016.03.006. Epub 2016 Mar 19

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