Scientific publications

Functional neuroimaging in the diagnosis of patients with Parkinsonism: Update and recommendations for clinical use

Arbizu J [SP] (1), Luquin MR (2), Abella J (3), de la Fuente-Fernández R (3), Fernandez-Torrón R (4), García-Solís D (5), Garrastachu P (6), Jiménez-Hoyuela JM (7), Llaneza M (3), Lomeña F (8), Lorenzo-Bosquet C (9), Martí MJ (10), Martinez-Castrillo JC (11), Mir P (12), Mitjavila M (13), Ruiz-Martínez J (14), Vela L (15).
(1) Grupo de Trabajo de Neuroimagen de la SEMNIM, Servicio de Medicina Nuclear, Clínica Universidad de Navarra, Pamplona, España.
(2) Grupo de Trastornos del Movimiento de la SEN, Departamento de Neurología, Clínica Universidad de Navarra, Pamplona, España.
(3) Servicio de Neurología, Hospital A, Marcide, Ferrol, España.
(4) Servicio de Neurología, Hospital Universitario Donostia, Área de Neurociencias, Instituto de Investigación Biodonostia, CIBERNED, San Sebastián, España.
(5) Servicio de Medicina Nuclear, UDIM, Hospital Universitario Virgen del Rocío, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Sevilla, España.
(6) Servicio de Medicina Nuclear, Hospital San Pedro, CIBIR, Logroño, España.
(7) Servicio de Medicina Nuclear, Hospital Universitario Virgen de la Victoria, Málaga, España.
(8) Servicio de Medicina Nuclear, Hospital Clinic, Barcelona, España.
(9) Servicio de Medicina Nuclear, Hospital Vall d́Hebron, CETIR-ERESA, Unitat Teknon, Barcelona, España.
(10) Unidad de Parkinson y Trastornos del Movimiento, Servicio de Neurología, ICN, CIBERNET, Hospital Clinic, Barcelona, España.
(11) Servicio de Neurología, Hospital Ramón y Cajal, Madrid, España.
(12) Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Sevilla, España.
(13) Servicio de Medicina Nuclear, Hospital Universitario Puerta de Hierro, Madrid, España.
(14) Unidad de Parkinson y otros Trastornos del Movimiento, Servicio de Neurología, Hospital Universitario Donostia, CIBERNED, Instituto de Salud Carlos III, San Sebastián (Guipúzcoa), España.
(15) Servicio de Neurología, Hospital Universitario Fundación Alcorcón, Alcorcón, España. 

Magazine: Revista Española de Medicina Nuclear e Imagen Molecular

Date: Aug 1, 2014

Neurology [SP] Nuclear Medicine [SP]

ABSTRACT

Functional Neuroimaging has been traditionally used in research for patients with different Parkinsonian syndromes. However, the emergence of commercial radiotracers together with the availability of single photon emission computed tomography (SPECT) and, more recently, positron emission tomography (PET) have made them available for clinical practice.

Particularly, the development of clinical evidence achieved by functional neuroimaging techniques over the past two decades have motivated a progressive inclusion of several biomarkers in the clinical diagnostic criteria for neurodegenerative diseases that occur with Parkinsonism.

However, the wide range of radiotracers designed to assess the involvement of different pathways in the neurodegenerative process underlying Parkinsonian syndromes (dopaminergic nigrostriatal pathway integrity, basal ganglia and cortical neuronal activity, myocardial sympathetic innervation), and the different neuroimaging techniques currently available (scintigraphy, SPECT and PET), have generated some controversy concerning the best neuroimaging test that should be indicated for the differential diagnosis of Parkinsonism.

In this article, a panel of nuclear medicine and neurology experts has evaluated the functional neuroimaging techniques emphazising practical considerations related to the diagnosis of patients with uncertain origin parkinsonism and the assessment Parkinson's disease progression.

CITATION  Rev Esp Med Nucl Imagen Mol. 2014 Jul-Aug;33(4):215-26. doi: 10.1016/j.remn.2014.02.001. Epub 2014 Apr 14.

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