Scientific publications

Enduring Changes in Decision Making in Patients with Full Remission from Anorexia Nervosa

Steward T (1,2), Mestre-Bach G (1,2), Agüera Z (1,2), Granero R (2,3), Martín-Romera V (4), Sánchez I (1,2), Riesco N (1,2), Tolosa-Sola I (1), Fernández-Formoso JA (2), Fernández-García JC (2,5), Tinahones FJ (2,5), Casanueva FF (2,6), Baños RM (2,7), Botella C (2,8), Crujeiras AB (2,6), de la Torre R (2,9,10), Fernández-Real JM (2,11), Frühbeck G [SP] (2,12), Ortega FJ (2,11), Rodríguez A [SP] (2,12), Jiménez-Murcia S (1,2,13), Menchón JM (1,13,14), Fernández-Aranda F (1,2,13).
(1) Department of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain.
(2) CIBER Fisiopatologia Obesidad y Nutrición (CIBEROBN), Instituto Salud Carlos III, Barcelona, Spain.
(3) Departament de Psicobiologia i Metodologia de les Ciències de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain.
(4) Departament de Psicologia Clínica, Universitat Autònoma de Barcelona, Barcelona, Spain.
(5) Department of Diabetes, Endocrinology and Nutrition, Hospital Clínico Universitario Virgen de Victoria, Málaga, Spain.
(6) Department of Medicine, Endocrinology Division, Santiago de Compostela University, Complejo Hospitalario Universitario, Santiago de Compostela, Spain.
(7) Department of Psychological, Personality, Evaluation and Treatment of the University of Valencia, Valencia, Spain.
(8) Department of Basic Psychology, Clinic and Psychobiology of the University Jaume I, Castelló, Spain.
(9) Integrated Pharmacology and Systems Neurosciences Research Group, Neuroscience Research Program Organization IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
(10) Department of Health and Experimental Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
11) Department of Diabetes, Endocrinology and Nutrition, Institu d'Investigació, Biomèdica de Girona (IdIBGi), Hospital Dr Josep Trueta, Girona, Spain.
(12) Metabolic Research Laboratory, Clínica Universidad de Navarra, University of Navarra-IdiSNA, Pamplona, Spain.
(13) Department of Clinical Sciences, School of Medicine, University of Barcelona, Spain.
(14) CIBER Salud Mental (CIBERSAM), Instituto Salud Carlos III, Barcelona, Spain. 

Magazine: European Eating Disorders Review

Date: Aug 31, 2016

Endocrinology and Nutrition [SP]

BACKGROUND:
Deficits in neuropsychological functioning have consistently been identified in patients with anorexia nervosa (AN). However, little is known on how decision making in AN patients evolves in response to treatment or whether impairments are reversible.

METHOD:
AN patients (n = 42) completed the Iowa Gambling Task (IGT) upon admission to a 3-month day-hospital treatment programme and at a 1-year follow-up. Patient IGT performance was compared to age-matched controls (n = 46).

RESULTS:
AN patients displayed poorer performance on the IGT at admission compared to controls (p < .001). Patients with full remission (n = 31; 73.9%) at the 1-year follow-up improved IGT performance (p = 0.007), and scores were similar compared to controls (p = 0.557). AN patients with partial/no remission at follow-up (n = 11; 26.1%) did not improve IGT scores (p = 0.867).

CONCLUSIONS:
These findings uphold that enduring remission from AN can reverse decision-making impairments, and they might be most likely explained by clinical state rather than a trait vulnerability.

CITATION  Eur Eat Disord Rev. 2016 Aug 31. doi: 10.1002/erv.2472

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