Scientific publications

Emphysema scores predict death from COPD and lung cancer

Zulueta JJ, Wisnivesky JP, Henschke CI, Yip R, Farooqi AO, McCauley DI, Chen M, Libby DM, Smith JP, Pasmantier MW, Yankelevitz DF.
Department of Pulmonary Medicine, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain.

Magazine: Chest

Date: May 14, 2012

Pneumology

OBJECTIVE
Our objective was to assess the usefulness of emphysema scores in predicting death from COPD and lung cancer.

METHODS
Emphysema was assessed with low-dose CT scans performed on 9,047 men and women for whom age and smoking history were documented. Each scan was scored according to the presence of emphysema as follows: none, mild, moderate, or marked. Follow-up time was calculated from time of CT scan to time of death or December 31, 2007, whichever came first. Cox regression analysis was used to calculate the hazard ratio (HR) of emphysema as a predictor of death.

RESULTS
Median age was 65 years, 4,433 (49%) were men, and 4,133 (46%) were currently smoking or had quit within 5 years. Emphysema was identified in 2,637 (29%) and was a significant predictor of death from COPD (HR, 9.3; 95% CI, 4.3-20.2; P < .0001) and from lung cancer (HR, 1.7; 95% CI, 1.1-2.5; P = .013), even when adjusted for age and smoking history.

CONCLUSIONS
Visual assessment of emphysema on CT scan is a significant predictor of death from COPD and lung cancer.

CITA DEL ARTÍCULO   2012 May;141(5):1216-23. Epub 2011 Oct 20

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