Effectiveness of the antibiotic lock therapy for the treatment of port-related enterococci, Gram-negative, or Gram-positive bacilli bloodstream infections
Jose L. Del Pozo (a,b), Marta Alonso (b), Alicia Serrera (b), Silvia Hernaez (b), Aitziber Aguinaga (b) and Jose Leiva (b)
(a) Division of Infectious Diseases, Clínica Universitaria de Navarra, Pamplona, Spain
(b) Department of Clinical Microbiology, Clínica Universitaria de Navarra, Pamplona, Spain
Magazine: Diagnostic Microbiology and Infectious Disease
Date: Jan 1, 2009Clinical Microbiology [SP] Infectious Diseases [SP]
The purpose of this study is to evaluate the efficacy of antibiotic lock therapy to treat port-related enterococci, Gram-negative, or Gram-positive bacilli bloodstream infections.
PATIENTS AND METHODS
We conducted a prospective observational study including all patients with port-related bacteremia diagnosed at the Clinica Universitaria de Navarra, Pamplona, Spain. During a 36-month period, 110 patients were diagnosed with port-related bacteremia. Of these patients, 18 met criteria to be enrolled in the study. They were treated with a combination of systemic and antibiotic lock therapy (12-24 h/day during 7-14 days). Treatment effectiveness was assessed by clinical and microbiologic criteria.
Treatment was associated with clinical and microbiologic success in 88.8% of our patients (2/2 of the Propionibacterium acnes, 5/5 of the Corynebacterium spp., 6/7 of the Gram-negative bacillus, and 3/4 of the Enterococcus faecium port-related bloodstream infections). Mean increase of port life span for all patients after bacteremia was 288 days (range, 0-1403 days).
Antibiotic lock therapy combined with systemic antibiotics appears to be a safe and effective treatment of port-related bacteremia caused by enterococci, Gram-negative, or Gram-positive bacilli if the patient is stable and no septic syndrome is associated.
CITATION Diagn Microbiol Infect Dis. 2009 Feb;63(2):208-12
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