Effectiveness of the antibiotic lock therapy for the treatment of port-related enterococci, Gram-negative, or Gram-positive bacilli bloodstream infections
Jose L. Del Pozo [SP] (a,b), Marta Alonso (b), Alicia Serrera (b), Silvia Hernaez (b), Aitziber Aguinaga (b) and Jose Leiva [SP] (b)
(a) Division of Infectious Diseases, Clínica Universitaria de Navarra, Pamplona, Spain
(b) Department of Clinical Microbiology, Clínica Universitaria de Navarra, Pamplona, Spain
Magazine: Diagnostic Microbiology and Infectious Disease
Date: Jan 1, 2009Clinical Microbiology [SP] Infectious Diseases [SP]
The purpose of this study is to evaluate the efficacy of antibiotic lock therapy to treat port-related enterococci, Gram-negative, or Gram-positive bacilli bloodstream infections.
PATIENTS AND METHODS
We conducted a prospective observational study including all patients with port-related bacteremia diagnosed at the Clinica Universitaria de Navarra, Pamplona, Spain. During a 36-month period, 110 patients were diagnosed with port-related bacteremia. Of these patients, 18 met criteria to be enrolled in the study. They were treated with a combination of systemic and antibiotic lock therapy (12-24 h/day during 7-14 days). Treatment effectiveness was assessed by clinical and microbiologic criteria.
Treatment was associated with clinical and microbiologic success in 88.8% of our patients (2/2 of the Propionibacterium acnes, 5/5 of the Corynebacterium spp., 6/7 of the Gram-negative bacillus, and 3/4 of the Enterococcus faecium port-related bloodstream infections). Mean increase of port life span for all patients after bacteremia was 288 days (range, 0-1403 days).
Antibiotic lock therapy combined with systemic antibiotics appears to be a safe and effective treatment of port-related bacteremia caused by enterococci, Gram-negative, or Gram-positive bacilli if the patient is stable and no septic syndrome is associated.
CITATION Diagn Microbiol Infect Dis. 2009 Feb;63(2):208-12
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