Effect of 3-hydroxyanthranilic acid in the immunosuppressive molecules indoleamine dioxygenase and HLA-G in macrophages
López AS, Alegre E [SP], Díaz-Lagares A, García-Girón C, Coma MJ, González A.
Oncology Area, Research Unit, General Yagüe Hospital, Burgos, Spain.
Magazine: Immunology letters
Date: Feb 1, 2008Biochemistry [SP]
Indoleamine 2,3-dioxygenase (IDO) and human leukocyte antigen-G (HLA-G) are two molecules involved in immune tolerance. 3-Hydroxyanthranilic acid is an IDO downstream metabolite that can produce an important immune suppression. In dendritic cells, it induces HLA-G cell surface expression and secretion to the medium.
The relationship between IDO and HLA-G seems to be dependent on the cell type. In this study we analyzed the effect of the tryptophan metabolite 3-hydroxyanthranilic acid in these two proteins in monocytes and macrophages.
This compound decreased IDO activity while increased HLA-G surface expression in macrophages, but not in monocytes. Also, 3-hydroxyanthranilic acid decreased HLA-G1 shedding, but not HLA-G5 secretion by macrophages. These results stress the importance of 3-hydroxyanthranilic acid as a modulator of the immune response.
CITATION Immunol Lett. 2008 Apr 15;117(1):91-5. Epub 2008 Feb 4.
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