Scientific publications

Effect of aspirin on beta-receptors in lymphocytes from patients with aspirin-induced asthma

Costa-Manso E, Sanz ML [SP], Croce M, Córdoba H, Oehling A.
Department of Allergology and Clinical Immunology, University Clinic, School of Medicine, University of Navarra, Pamplona, Spain.

Magazine: Journal of Investigational Allergology and Clinical Immunology

Date: Dec 1, 1993

Allergology and Immunology Department

We studied the effect of aspirin on beta-adrenergic receptors in lymphocytes from three groups of subjects: 5 asthmatic patients presenting sensitivity to aspirin, 10 asthmatic patients with tolerance to aspirin and a control group. Lymphocytes were incubated with aspirin-lysine (36 micrograms/ml).

The number of beta-receptors/cell and the dissociation constants (Kd) were assessed by means of [125I]-cyanopindolol (ICYP). There was a decrease in the number of beta-receptors after incubation with aspirin in all asthmatic patients with sensitivity. The differences between mean basal (660 +/- 171 receptors/cell) and postincubation (398 +/- 110 receptors/cell) values were significant (p < 0.05). There were also significant differences (p < 0.01) between basal (23.4 +/- 6 pM) and postincubation (15 +/- 5.1 pM) Kd values, which indicates that the affinity of ICYP increased. In the subjects in the other two groups, aspirin both increased and decreased the number of beta-receptors, but the effects were not significant.

It is suggested that in patients with sensitivity, aspirin could induce changes in the plasmatic membrane, thus altering beta-receptors or inducing the release of inflammatory mediators that exert their effect upon these receptors.

CITATION  J Investig Allergol Clin Immunol. 1993 Nov-Dec;3(6):288-93



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