Early diagnosis of an allergic reaction to cisatracurium
Goikoetxea MJ [SP] (1), Lafuente A [SP], de la Borbolla JM, Moncada R, Sanz ML [SP], Gastaminza G [SP].
(1) Department of Allergy and Clinical Immunology, Clínica Universidad de Navarra, Pamplona, Spain.
Magazine: Journal of Investigational Allergology and Clinical Immunology
Date: Jun 1, 2013Anesthesia and Intensive Care [SP] Allergology and Immunology Department
The mortality of allergic reactions during anesthesia is estimated to be 6%, and between 1/10 000 and 1/1250 anesthetized patients die from such a reaction [1,2].
Given their quaternary ammonium structure, neuromuscular blocking agents (NMBAs) can behave as antigens. Consequently, they are responsible for more than two-thirds of anaphylactic or anaphylactoid reactions and for 80% of cases of anaphylactic shock during anesthesia .
The nondepolarizing muscle relaxant, cisatracurium, induces fewer allergic reactions than other NMBAs , such as succinylcholine, whose administration entails a higher risk than most of the other commonly used agents.
CITATION J Investig Allergol Clin Immunol. 2013;23(1):69-71
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