Distal internal carotid artery dissecting aneurysm
Angeli SI, Alcalde J [SP], Hoffman HT, Smith RJ.
Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City 52242.
Magazine: The Annals of Otology, Rhinology and Laryngology
Date: Mar 1, 1995Otorhinolaryngology
This is a retrospective analysis of a 29-year institutional experience with Langerhans' cell histiocytosis (LCH) in children. Cases of LCH were categorized by disease extent into three groups: group 1, with a solitary focus of LCH; group 2, with multiple non-vital organ foci; and group 3, with vital organ disease. Sixteen patients averaging 7.3 years of age and with 11.0 years of follow-up presented in group 1. One child experienced a spontaneous remission; all other children responded to local treatment.
The skull was the most common site of involvement. Eight children averaging 4.6 years in age and with 8.0 years of follow-up presented in group 2; 3 children had diabetes insipidus. Treatment included radical surgery, radiotherapy, and chemotherapy; however, disease persisted in all patients. Iatrogenic complications were a significant cause of morbidity and mortality. Only 1 patient, 1 year of age, presented with lung and liver involvement (group 3).
He died after a fulminant course. Current recommendations for diagnosis, evaluation, and treatment of LCH are discussed.
CITATION Ann Otol Rhinol Laryngol. 1995 Mar;104(3):173-80.
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