Scientific publications

Control of body weight: a physiologic and transgenic perspective

Frühbeck G [SP], Gómez-Ambrosi J [SP].
Department of Endocrinology, Clínica Universitaria de Navarra, University of Navarre, Avda. Pío XII 36, 31008 Pamplona, Spain

Magazine: Diabetologia

Date: Feb 1, 2003

Obesity Unit Endocrinology and Nutrition [SP]

In mammals, body weight is normally regulated around a set point by coordinated changes in food intake and energy expenditure.

These changes are integrated under the influence of specific neural pathways and circulating signals. Almost 50 years ago it was first proposed that circulating signals generated in proportion to body fat stores influence appetite and energy expenditure in a coordinated manner to regulate body weight.

Of particular historical value are the classic parabiosis experiments which provided evidence that such circulating signals exist.

CITATION  Diabetologia. 2003 Feb;46(2):143-72

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