Scientific publications

Concurrent clarithromycin and cyclosporin A treatment

Sádaba B [SP], López de Ocáriz A, Azanza JR [SP], Quiroga J [SP], Cienfuegos JA.
Clinical Pharmacology Department, University Clinic of Navarra School of Medicine, Pamplona, Spain.

Magazine: The Journal of Antimicrobial Chemotherapy

Date: Sep 1, 1998

Hepatology Clinical Research Unit [SP] Clinical Pharmacology [SP]

Although macrolides have been associated with significant pharmacokinetic interactions, clarithromycin is considered to have a low interaction capacity. In this study, six transplant recipients treated with cyclosporin A also received clarithromycin. In all patients, the dose of cyclosporin A had to be reduced by a mean of 33% per day depending on the macrolide dose.

Normalization of the dosage parameters began on the fourth day after stopping clarithromycin treatment. Co-administration of cyclosporin A and clarithromycin may lead to increases in whole blood cyclosporin levels, and appropriate dose reductions should be considered.

CITATION  J Antimicrob Chemother. 1998 Sep;42(3):393-5

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