Comparison of limited-volume perioperative high-dose-rate brachytherapy and wide-field external irradiation in resected head and neck cancer
Gaztañaga M, Pagola M, Cambeiro M [SP], Ruiz ME, Aristu J [SP], Montesdeoca N, Alcalde J [SP], Martínez-Monge R.
Department of Radiation, Clínica Universitaria de Navarra, University of Navarre, Navarre, Spain.
Magazine: Head & Neck
Date: Jan 1, 2012Otorhinolaryngology Radiation Oncology
This study aimed to test the safety of using perioperative high-dose-rate brachytherapy (PHDRB) in resected head and neck cancer.
From 2000 to 2008, 97 patients received PHDRB after complete macroscopic resection. Group 1 (previously irradiated patients) received 32 to 40 Gray (Gy) of PHDRB in 8 to 10 twice-daily (bid) treatments (R0-R1 resections). Group 2 (unirradiated patients) received 16 to 24 Gy of PHDRB in 4 to 6 bid treatments (R0-R1 resections) followed by external beam irradiation (EBRT) of 45 Gy/25 daily fractions ± concomitant chemotherapy.
The median follow-up was 4.3 years. The cumulative hazard of 2-year grade ≥ 3 complications in group 1 was 45.9%, and the rate of grade ≥ 3 complications in group 2 was 24.6%. Actuarial locoregional control at 2 and 5 years for group 1 was 60.9% and for group 2, 84.1% and 79.4%.
Complications and locoregional failure rates were similar to those reported in the reference standards despite a much smaller treatment volume.
CITATION Head Neck. 2012 Aug;34(8):1081-8. doi: 10.1002/hed.21874. Epub 2012 Jan 20
you mayBE INTERESTED
The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.
The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.
Learn why we are different from other healthcare centers. Quality, speed, comfort and results.