Scientific publications

Comparative study of intubating conditions at the first minute with suxamethonium, rocuronium and different priming techniques of rocuronium

Ortiz-Gómez JR, Carrascosa F [SP], Percaz-Bados JA [SP], Añez C.
University Clinic, Department of Anesthesiology and Intensive Care, Navarra, Spain.

Magazine: European Journal of Anaesthesiology

Date: Apr 1, 2005

Pain Unit [SP] Anesthesia and Intensive Care [SP]

BACKGROUND AND OBJECTIVE
To evaluate orotracheal intubation conditions after 1 min.

PATIENTS AND METHODS
A prospective randomized study with 376 adult American Society of Anesthesiologists (ASA) Grade I-III patients. Each patient received propofol, fentanyl and either suxamethonium (1 mg kg(-1)) or rocuronium.

The intubating dose of rocuronium (2 x ED95) was preceded 4 min earlier by saline, or a 0.1 x ED95 priming dose of rocuronium, atracurium, cis-atracurium, vecuronium or mivacurium. Intubating conditions were graded as excellent, good or poor with respect to laryngoscopy, vocal cord position and movement and reaction to intubation and/or cuff inflation.

RESULTS
There were significant differences (P < 0.05) in laryngoscopy between suxamethonium and rocuronium primed with saline, atracurium or cis-atracurium. With respect to vocal cord position and movement during intubation, rocuronium without priming differed significantly from all other groups and for reaction to insertion of tracheal tube and/or cuff inflation. Rocuronium without priming differed significantly from all other groups except for rocuronium primed with itself. The mivacurium group showed more signs of pre-curarization than other groups (P < 0.05). There were significant differences between rocuronium alone and the other groups when final intubating conditions were compared.

CONCLUSIONS
Priming rocuronium with 0.1 x ED95 of vecuronium, rocuronium, atracurium or cis-atracurium is a safe technique and did not increase risk of pre-curarization in healthy patients.

CITATION  Eur J Anaesthesiol. 2005 Apr;22(4):263-8.

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