Scientific publications

Comparative Evaluation of Four Risk Scores for Predicting Mortality in Patients With Implantable Cardioverter-defibrillator for Primary Prevention

Rodríguez-Mañero M (1), Abu Assi E (1), Sánchez-Gómez JM (2), Fernández-Armenta J (3), Díaz-Infante E (4), García-Bolao I (5), Benezet-Mazuecos J (6), Andrés Lahuerta A (7), Expósito-García V (8), Bertomeu-González V (9), Arce-León Á (10), Barrio-López MT (11), Peinado R (12), Martínez-Sande L (1), Arias MA (13).
(1) Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.
(2) Unidad de Arritmias, Servicio de Cardiología, Hospital Clínico Universitario de Valencia, Valencia, Spain.
(3) Unidad de Arritmias, Servicio de Cardiología, Hospital Puerta del Mar, Cádiz, Spain.
(4) Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen Macarena, Seville, Spain.
(5) Unidad de Arritmias, Servicio de Cardiología, Clínica Universidad de Navarra, Pamplona, Navarra, Spain.
(6) Unidad de Arritmias, Servicio de Cardiología, Hospital Fundación Jiménez Díaz, Madrid, Spain.
(7) Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario La Fe, Valencia, Spain.
(8) Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain.
(9) Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario San Juan, Sant Joan d'Alacant, Alicante, Spain.
(10) Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Seville, Spain.
(11) Unidad de Arritmias, Servicio de Cardiología, Hospital Virgen de las Nieves, Granada, Spain.
(12) Sección de Electrofisiología y Arritmias, Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain.
(13) Unidad de Arritmias y Electrofisiología Cardiaca, Servicio de Cardiología, Hospital Virgen de la Salud, Toledo, Spain 

Magazine: Revista Española de Cardiología

Date: Aug 1, 2016

Cardiology

INTRODUCTION AND OBJECTIVES:
Several clinical risk scores have been developed to identify patients at high risk of all-cause mortality despite implantation of an implantable cardioverter-defibrillator. We aimed to examine and compare the predictive capacity of 4 simple scoring systems (MADIT-II, FADES, PACE and SHOCKED) for predicting mortality after defibrillator implantation for primary prevention of sudden cardiac death in a Mediterranean country.

METHODS:
A multicenter retrospective study was performed in 15 Spanish hospitals. Consecutive patients referred for defibrillator implantation between January 2010 and December 2011 were included.

RESULTS:
A total of 916 patients with ischemic and nonischemic heart disease were included (mean age, 62 ± 11 years, 81.4% male). Over 33.4 ± 12.9 months, 113 (12.3%) patients died (cardiovascular origin in 86 [9.4%] patients). At 12, 24, 36, and 48 months, mortality rates were 4.5%, 7.6%, 10.8%, and 12.3% respectively.

All the risk scores showed a stepwise increase in the risk of death throughout the scoring system of each of the scores and all 4 scores identified patients at greater risk of mortality.

The scores were significantly associated with all-cause mortality throughout the follow-up period. PACE displayed the lowest c-index value regardless of whether the population had heart disease of ischemic (c-statistic = 0.61) or nonischemic origin (c-statistic = 0.61), whereas MADIT-II (c-statistic = 0.67 and 0.65 in ischemic and nonischemic cardiomyopathy, respectively), SHOCKED (c-statistic = 0.68 and 0.66, respectively), and FADES (c-statistic = 0.66 and 0.60) provided similar c-statistic values (P ≥ .09).

CONCLUSIONS:
In this nontrial-based cohort of Mediterranean patients, the 4 evaluated risk scores showed a significant stepwise increase in the risk of death. Among the currently available risk scores, MADIT-II, FADES, and SHOCKED provide slightly better performance than PACE.

CONCLUSIONS:
In this nontrial-based cohort of Mediterranean patients, the 4 evaluated risk scores showed a significant stepwise increase in the risk of death. Among the currently available risk scores, MADIT-II, FADES, and SHOCKED provide slightly better performance than PACE.

CITATION  Rev Esp Cardiol (Engl Ed). 2016 Nov;69(11):1033-1041. doi: 10.1016/j.rec.2016.03.027. Epub 2016 Aug 2.

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