Scientific publications

Combination of ondansetron and dexamethasone in the prophylaxis of postoperative nausea and vomiting

López-Olaondo L [SP], Carrascosa F [SP], Pueyo FJ [SP], Monedero P [SP], Busto N, Sáez A.
Department of Anaesthesiology and Critical Care, University of Navarra, Pamplona, Spain.

Magazine: British Journal of Anaesthesia

Date: Jun 1, 1996

Anesthesia and Intensive Care [SP]

We studied 100 ASA I-II females undergoing general anaesthesia for major gynaecological surgery, in a prospective, double-blind, placebo-controlled, randomized study.

Patients received one of four regimens for the prevention of postoperative nausea and vomiting (PONV): ondansetron 4 mg (n = 25), dexamethasone 8 mg (n = 25), ondansetron with dexamethasone (4 mg and 8 mg, respectively, n = 25) or placebo (saline, n = 25) There were no differences in background factors or factors related to operation and anaesthesia, morphine consumption, pain or side effects between groups. The incidence of nausea and emetic episodes in the ondansetron with dexamethasone group was lower than in the placebo (P < 0.01), ondansetron (P < 0.05) and dexamethasone (P = 0.057) groups. There were no differences between ondansetron and dexamethasone, and both were more effective than placebo (P < 0.05 and P < 0.01, respectively). Dexamethasone appeared to be preferable in preventing nausea than emetic episodes. Fewer patients in the ondansetron with dexamethasone group needed antimetic rescue (P < 0.01 vs placebo and P < 0.05 vs ondansetron).

We conclude that prophylactic administration of combined ondansetron and dexamethasone is effective in preventing PONV.

CITATION  Br J Anaesth. 1996 Jun;76(6):835-40



The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra


Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra