Scientific publications

Coagulation inhibitors in patients with neoplasms

Páramo JA, Cuesta B, Hernández M [SP], Fernández J, Paloma MJ, Rifón J, Rocha E.
Departamento de Hematología y Hemoterapia. Clinica Universitaria de Navarra. Pamplona. España.

Magazine: Medicina Clínica

Date: Feb 1, 1989

Cell Therapy Area [SP] Haematology and Hameotherapy

Mean plasma concentrations of the main inhibitors of blood coagulation antithrombin III (AT III), protein C and protein S were determined in 149 patients with different local and disseminated malignancies. Results were compared with findings in 44 healthy subjects.

No statistical significant differences for AT III, protein C and free protein S were found between patients and controls. However, total protein S showed a significant increase in the patient group (p less than 0.0003). None of the parameters analyzed showed differences according to the degree of tumoral activity nor to the tumour localization. We conclude that the main inhibitors of the blood coagulation seem not to play an important role in the pathogenesis of the hypercoagulable state in malignancy.

The increased levels in total protein S would indicate endothelial synthesis in response to thrombogenic stimuli.

CITATION  Med Clin (Barc). 1989 Feb 11;92(5):164-6

you mayBE INTERESTED

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra