Scientific publications

Clinical experience of treatment with onabotulinumtoxin A in patients with refractory migraine

Palma JA, Irimia P [SP], Fernandez-Torron R, Ortega-Cubero S, Riverol M [SP], Luquin MR, Martinez-Vila E.
Clinica Universitaria de Navarra, 31008 Pamplona, Espana.

Magazine: Revista de Neurología

Date: Jun 16, 2012

Neurology [SP]

AIM
To analyse our experience in the treatment of refractory chronic migraine, episodic frequent refractory migraine (>= 10 days/month), with onabotulinumtoxin A (OnabotA).

PATIENTS AND METHODS
Retrospective analysis of patients with refractory migraine who underwent, at least two sessions of OnabotA pericranial injections following the PREEMPT protocol between 2008 and 2012. The efficacy of OnabotA was evaluated comparing the basal situation with 12-16 weeks after the second session. We analysed the subjective improvement of the patients, number of days with headache, preventive and abortive drugs consumption, and adverse effects.

RESULTS
Forty-one patients (37 women, 4 male) were identified. 65.8% patients experienced subjective improvement after OnabotA treatment. 36.58% responded (reduction of > 50% in headache days). Differences between days with headache before the first session (24.5 ± 7.3), and 12-16 weeks after the second session (17.4 ± 11.6), as well as the differences between the number of abortive drugs taken before the first session (26.8 ± 23.1) and 12-16 weeks after the second session (16.7 ± 19.3), were statistically significant (p < 0.001). Subgroups analysis showed that all differences were significant, except for the reduction of the number of days with headache in patients with episodic frequent refractory migraine.

CONCLUSION
Our work shows that treatment with OnabotA is safe and useful in patients with episodic and chronic refractory migraine, including those patients with medication overuse headache.

CITATION  Rev Neurol. 2012 Jun 16;54(12):705-11

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