Scientific publications

Circulating omentin concentration increases after weight loss

Moreno-Navarrete JM, Catalán V [SP], Ortega F, Gómez-Ambrosi J [SP], Ricart W, Frühbeck G [SP], Fernández-Real JM.
Service of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi) Hospital Dr Josep Trueta, Girona, 17007, CIBEROBN (CB06/03/010), Spain.

Magazine: Nutrition and Metabolism

Date: Apr 1, 2010

Obesity Unit Endocrinology and Nutrition [SP]

Background
Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance and obesity. We aimed to study the effects of weight loss-induced improved insulin sensitivity on circulating omentin concentrations.

Methods
Circulating omentin-1(ELISA) concentration in association with metabolic variables was measured in 35 obese subjects (18 men, 17 women) before and after hypocaloric weight loss.

Results
Baseline circulating omentin-1 concentrations correlated negatively with BMI (r = -0.58, p < 0.001), body weight (r = -0.35, p = 0.045), fat mass (r = -0.67, p < 0.001), circulating leptin (r = -0.7, p < 0.001) and fasting insulin (r = -0.37, p = 0.03). Circulating omentin-1 concentration increased significantly after weight loss (from 44.9 +/- 9.02 to 53.41 +/- 8.8 ng/ml, p < 0.001). This increase in circulating omentin after weight loss was associated with improved insulin sensitivity (negatively associated with HOMA value and fasting insulin, r = -0.42, p = 0.02 and r = -0.45, p = 0.01, respectively) and decreased BMI (r = -0.54, p = 0.001).

Conclusion
As previously described with adiponectin, circulating omentin-1 concentrations increase after weight loss-induced improvement of insulin sensitivity.

CITATION  Nutr Metab (Lond). 2010 Apr 9;7:27.

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