Basophil activation tests in the evaluation of immediate drug hypersensitivity
Sanz, María L [SP] (a); Gamboa, Pedro M (b); Mayorga, Cristobalina (c)
(a) Department of Allergology and Clinical Immunology, University Clinic of Navarra, School of Medicine, University of Navarra, Pamplona, Spain
(b) Servicio de Alergia, Hospital Basurto, Bilbao, Spain
(c) Unidad de Investigación, Hospital Carlos Haya, Málaga, Spain
Magazine: Current Opinion in Allergy and Clinical Immunology
Date: Aug 1, 2009Allergology and Immunology Department
PURPOSE OF REVIEW
The aim of this study was to confirm the applicability of the basophil activation test (BAT) in the in-vitro diagnosis of drug allergy reactions.
The results obtained in terms of sensitivity and specificity with BAT are encouraging and in significant number of cases can establish the diagnosis.
BAT sensitivity in beta-lactam allergy was 50%, and specificity ranged from 89 to 97%. There are several studies to validate the BAT in allergy to muscle relaxants showing a sensitivity ranging from 54 to 64% with a specificity of 100 and 93%. The sensitivity of a test for evaluating immediate allergic reactions to drugs may decrease over time. To date, the BAT is the only in-vitro diagnostic method that has been validated for the diagnosis of both IgE-mediated and hypersensitivity reactions to NSAIDs.
With respect to other drugs, they are nonetheless interesting as they include the evaluation of allergy to drugs that cannot be studied by other in-vitro techniques. All these data suggest that although a full validation of the test is required, BAT is a potential diagnostic method for evaluating immediate allergic reactions to drugs and NSAID hypersensitivity reactions.
CITATION Curr Opin Allergy Clin Immunol. 2009 Aug;9(4):298-304
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