Scientific publications

Basophil activation tests in the evaluation of immediate drug hypersensitivity

Sanz, María L [SP] (a); Gamboa, Pedro M (b); Mayorga, Cristobalina (c)
(a) Department of Allergology and Clinical Immunology, University Clinic of Navarra, School of Medicine, University of Navarra, Pamplona, Spain
(b) Servicio de Alergia, Hospital Basurto, Bilbao, Spain
(c) Unidad de Investigación, Hospital Carlos Haya, Málaga, Spain

Magazine: Current Opinion in Allergy and Clinical Immunology

Date: Aug 1, 2009

Allergology and Immunology Department

PURPOSE OF REVIEW
The aim of this study was to confirm the applicability of the basophil activation test (BAT) in the in-vitro diagnosis of drug allergy reactions.

RECENT FINDINGS
The results obtained in terms of sensitivity and specificity with BAT are encouraging and in significant number of cases can establish the diagnosis.

SUMMARY
BAT sensitivity in beta-lactam allergy was 50%, and specificity ranged from 89 to 97%. There are several studies to validate the BAT in allergy to muscle relaxants showing a sensitivity ranging from 54 to 64% with a specificity of 100 and 93%. The sensitivity of a test for evaluating immediate allergic reactions to drugs may decrease over time. To date, the BAT is the only in-vitro diagnostic method that has been validated for the diagnosis of both IgE-mediated and hypersensitivity reactions to NSAIDs.

With respect to other drugs, they are nonetheless interesting as they include the evaluation of allergy to drugs that cannot be studied by other in-vitro techniques. All these data suggest that although a full validation of the test is required, BAT is a potential diagnostic method for evaluating immediate allergic reactions to drugs and NSAID hypersensitivity reactions.

CITATION  Curr Opin Allergy Clin Immunol. 2009 Aug;9(4):298-304

you mayBE INTERESTED

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra