Scientific publications

Arterial spin labeling MRI is able to detect early hemodynamic changes in diabetic nephropathy

Mora-Gutiérrez JM (1), Garcia-Fernandez N (1), Slon Roblero MF (2), Páramo JA (3), Escalada FJ (4), Wang DJ (5), Benito A (6), Fernández-Seara MA (6,7).

(1) Nephrology, Clínica Universidad de Navarra, Pamplona, Spain.
(2) Nephrology, Navarra Hospital, Pamplona, Spain.
(3) Atherosclerosis Research Laboratory, CIMA, University of Navarra, Pamplona, Spain.
(4) Endocrinology, Clínica Universidad de Navarra, Pamplona, Spain.
(5) Laboratory of Functional MRI Technology (LOFT) Stevens Neuroimaging and Informatics Institute University of Southern California, Los Angeles, California, USA.
(6) Radiology, Clínica Universidad de Navarra, Spain.
(7) Adjunct Associate Professor of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Magazine: Journal of Magnetic Resonance Imaging

Date: Apr 6, 2017

Haematology and Hameotherapy Endocrinology and Nutrition [SP] Nephrology [SP] Radiology [SP]

PURPOSE:
To investigate whether arterial spin labeling (ASL) MRI could detect renal hemodynamic impairment in diabetes mellitus (DM) along different stages of chronic kidney disease (CKD).

MATERIALS AND METHODS:
Three Tesla (3T) ASL-MRI was performed to evaluate renal blood flow (RBF) in 91 subjects (46 healthy volunteers and 45 type 2 diabetic patients). Patients were classified according to their estimated glomerular filtration rate (eGFR) as group I (eGFR > 60 mL/min/1.73 m2 ), group II (60 ≥ eGFR>30 mL/min/1.73 m2 ), or group III (eGFR ≤ 30 mL/min/1.73 m2 ), to determine differences depending on renal function. Studies were performed at 3T using a 12-channel flexible body array combined with the spine array coil as receiver.

RESULTS:
A 28% reduction in cortical RBF was seen in diabetics in comparison with healthy controls (185.79 [54.60] versus 258.83 [37.96] mL/min/100 g, P < 3 × 10-6 ). Differences were also seen between controls and diabetic patients despite normal eGFR and absence of overt albuminuria (RBF [mL/min/100 g]: controls=258.83 [37.96], group I=208.89 [58.83], P = 0.0018; eGFR [mL/min/1.73 m2 ]: controls = 95.50 [12.60], group I = 82.00 [20.76], P > 0.05; albumin-creatinine ratio [mg/g]: controls = 3.50 [4.45], group I = 17.50 [21.20], P > 0.05).

A marked decrease in RBF was noted a long with progression of diabetic nephropathy (DN) through the five stages of CKD (χ2  = 43.58; P = 1.85 × 10-9 ). Strong correlation (r = 0.62; P = 4 × 10-10 ) was obtained between RBF and GFR estimated by cystatin C.

CONCLUSION:
ASL-MRI is able to quantify early renal perfusion impairment in DM, as well as changes according to different CKD stages of DN. In addition, we demonstrated a correlation of RBF quantified by ASL and GFR estimated by cystatin C.

LEVEL OF EVIDENCE:
3 J. Magn. Reson. Imaging 2017.

CITATION J Magn Reson Imaging. 2017 Apr 6. doi: 10.1002/jmri.25717

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