Scientific publications

Androgen receptor mutations are associated with Gleason score in localized prostate cancer.

Sanchez D, Rosell D [SP], Honorato B, Lopez J, Arocena J, Sanz G.
Urology Department, Fundación Hospital Calahorra, Clínica Universitaria de Navarra, Spain.

Magazine: BJU International

Date: Dec 1, 2006

Urology [SP]

OBJECTIVE
To study human androgen receptor (hAR) mutations and their relationship to the clinical and pathological characteristics of patients with prostate cancer, as the mechanisms by which tumour cells escape androgen control and grow independently of hormone stimulation are unclear.

PATIENTS AND METHODS
In all, 67 radical prostatectomy specimens were sequenced genomically (mean age of the patients, 64 years; median prostate-specific antigen level 15 ng/mL; 34% T1 and 66% T2). Of the 66 patients who had a valid follow-up, 28 (43%) had biochemical progression during the follow-up.

RESULTS
There was mutation in the hAR in 11 patients (16%); nine types of different mutations were identified, only one of which was described previously in patients with prostate cancer. Patients with mutated hAR had statistically lower Gleason scores (P = 0.004) than had patients with native hAR.

CONCLUSION
hAR mutations have a different effect on the disease course in patients with localized than in those with metastatic prostatic cancer.

CITATION  BJU Int. 2006 Dec;98(6):1320-5.

you mayBE INTERESTED

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra