An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas
Melero I [SP], Gabari I, Corbí AL, Relloso M, Mazzolini G, Schmitz V, Rodriguez-Calvillo M, Tirapu I, Camafeita E, Albar JP, Prieto J.
Gene Therapy Unit, Department of Medicine, University of Navarra School of Medicine, C/Irunlarrea, I-31008 Pamplona, Spain
Magazine: Cancer Research
Date: Jun 1, 2002Immunology [SP] Hepatology
Monoclonal antibodies (mAbs) can mediate antitumor effects by indirect mechanisms involving antiangiogenesis and up-regulation of the cellular immune response rather than by direct tumor cell destruction. From mAbs raised by immunization of rats with transformed murine endothelial cells, a mAb (EOL4G8) was selected for its ability to eradicate a fraction of established colon carcinomas that did not express the EOL4G8-recognized antigen.
The antigen was found to be ICAM-2 (CD102). Antitumor effects of EOL4G8, which required a functional T-cell compartment, were abrogated by depletion of CD8(+) cells and correlated with antitumor CTL activity, whereas only a mild inhibition of angiogenesis was observed.
Interestingly, we found that EOL4G8 acting on endothelial ICAM-2 markedly enhances leukotactic factor activity-1-independent adhesion of immature dendritic cells to endothelium-an effect that is at least in part mediated by DC-SIGN (CD209).
CITATION Cancer Res. 2002 Jun 1;62(11):3167-74
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