Scientific publications

A typical antipsychotics normalize low-gamma evoked oscillations in patients with schizophrenia

Alegre M (1), Molero P (2), Valencia M (3), Mayner G (2), Ortuño F (2), Artieda J (4).
(1) Clinical Neurophysiology Section, Clínica Universidad de Navarra, Pamplona, Spain; Neurophysiology Laboratory, CIMA (Centre for Applied Medical Research) Universidad de Navarra, Pamplona, Spain.
(2) Department of Psychiatry, Clínica Universidad de Navarra, Pamplona, Spain.
(3) Neurophysiology Laboratory, CIMA (Centre for Applied Medical Research) Universidad de Navarra, Pamplona, Spain.
(4) Clinical Neurophysiology Section, Clínica Universidad de Navarra, Pamplona, Spain; Neurophysiology Laboratory, CIMA (Centre for Applied Medical Research) Universidad de Navarra, Pamplona, Spain 

Magazine: Psychiatry Research

Date: Nov 26, 2016

Psychiatry and Clinical Psychology [SP] Neurophysiology [SP]

ABSTRACT

The symptoms of schizophrenia might be mediated by a cortical network disconnection which may disrupt the cortical oscillatory activity. Steady-state responses are an easy and consistent way to explore cortical oscillatory activity.

A chirp-modulated tone (increasing the frequency of the modulation in a linear manner) allows a fast measure of the steady-state response to different modulation rates. With this approach, we studied the auditory steady-state responses in two groups of patients with schizophrenia (drug-naive and treated with atypical antipsychotic drugs), in order to assess the differences in their responses with respect to healthy subjects, and study any potential effect of medication.

Drug-naive patients had reduced amplitude and inter-trial phase coherence of the response in the 30-50Hz range, and reduced amplitude of the response in the 90-100Hz range, when compared to controls. In the treated patients group, the response in the 30-50Hz range was normalized to values similar to the control group, but the reduction in amplitude in the 90-100Hz range remained as in the drug-naive group.

These results suggest that gamma activity impairment in schizophrenia is a complex phenomenon that affects a wide band of frequencies and may be influenced by antipsychotic treatment.

CITATION  Psychiatry Res. 2016 Nov 26;247:214-221. doi: 10.1016/j.psychres.2016.11.030

you mayBE INTERESTED

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra