Scientific publications

A comparative study of the pharmacokinetics of ibuprofen arginate versus dexibuprofen in healthy volunteers

Sádaba B [SP], Campanero MA, Muñoz-Juarez MJ, Gil-Aldea I, García-Quetglas E, Esteras A, Azanza JR [SP].
Clinical Research Unit, Clínica Universitaria de Navarra, Universidad de Navarra, 31008, Pamplona, Spain.

Magazine: European Journal of Clinical Pharmacology

Date: Oct 1, 2006

Clinical Research Unit [SP] Clinical Pharmacology [SP]

OBJECTIVE
Ibuprofen arginate is a salt formulation of ibuprofen designed to reach target concentrations rapidly. The primary objective of this study was to compare the 12-h pharmacokinetic profile of S(+)-ibuprofen following administration of single doses of ibuprofen arginate (600 mg) and dexibuprofen (400 mg) in healthy volunteers.

METHODS
Twenty-four volunteers were recruited into an open-label, randomised, two-period, single-centre study with crossover design.

RESULTS
Both treatments were well tolerated. Ibuprofen arginate and dexibuprofen showed similar bioavailability for S(+)-ibuprofen. Compared with dexibuprofen, ibuprofen arginate demonstrated a 45% higher maximum concentration (C(max)), and a time to peak concentration (T(max)) 2 h sooner.

CONCLUSION
Ibuprofen arginate approaches maximum concentrations of S(+)-ibuprofen faster and higher than dexibuprofen.

CITATION  Eur J Clin Pharmacol. 2006 Oct;62(10):849-54

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